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Neurosteroids have a crucial role in neuroprotection, benefiting both the central and peripheral nervous systems Notably, the neurosteroid precursor preg has the ability to significantly mitigate the detrimental consequences of glutamate toxicity [108]. Neurosteroid therapy produces positive effects in experimental animal models or humans without causing harmful side effects However, the effects of synthetic neurosteroids are not always apparent in clinical.
Allopregnanolone, a major endogenous inhibitory neurosteroid Neurosteroids are natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors It includes inhibitory, excitatory, and neurotrophic neurosteroids as well as pheromones and vomeropherines In contrast to steroid hormones, neurosteroids have.
Therapeutic approaches aimed at neurosteroids are likely to yield beneficial effects The decline in neurosteroid levels and diminished neuroprotective capacity during aging may contribute to neurodegenerative processes, leading to increased apoptosis, neuronal cell loss, and decreased proliferation and differentiation of neural precursors [43].
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